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Bird flu. Is this report out of Louisiana worrisome? And if so, why? Well, it's one more sign that the drumbeat of bird flu coming closer to humans is becoming a major threat. So we've already seen this year that there have been a number of mammalian species close to humans that now have bird flu outbreaks. We have outbreaks in poultry in all 50 states. 16 states have outbreaks in cattle. In California, in the last 30 days, there have been more than 300 herds that tested positive. And now we have 66 cases of bird flu in humans. And this is almost certainly a significant undercount because we have not been doing nearly enough testing, so we really don't know the extent of bird flu that's out there in humans. But this particular case, it's someone who is severely ill. But not only that, researchers have isolated the virus in this individual who is sick in Louisiana. And they found that this particular strain of the virus appears to have acquired mutations that make it more likely to bind to airway receptors. Bird flu has been around for a long time. About 30 years. Yeah, exactly. But it hasn't been a major issue in humans because while it spreads among birds, it hasn't really spread among mammals. But now there is this mutation. And there's another concern now major too, which is that we are in flu season. And it's possible that a single person could have bird flu and seasonal flu at the same time. Something called reassortment. That's right. Where things change because of one illness becoming another illness through reassortment of a mutated virus. That's right. And so the viruses could exchange genes. You could develop a new hybrid virus. And if you now have a virus that's more contagious and causes more severe disease, that's when it becomes a major threat to humankind. What should be?